Vitamin E tocotrienol has become a hot item of study for many researchers. Besides its role as an antioxidant, the benefits of tocotrienols has started to be discovered in many other areas of health. A simple google search of ‘tocotrienol and cancer’, ‘tocotrienol and diabetes’, ‘tocotrienol and cholesterol’, etc., will yield a myriad of results about the vitamin. This article will explain some of the exciting research and health benefits associated with Vitamin E tocotrienols and its use in controlling cholesterol levels.
It should be noted that of all the forms of tocotrienol, the delta and gamma forms are the most potent. This is simply because the molecular structure of the ‘head’ region of the vitamin for those two forms leaves the molecule less restricted. It is able to work better as an antioxidant.
The cholesterol lowering effects of tocotrienols was first studied in 1991 by the University of Wisconsin. At first, patients received a mix of tocotrienols and tocopherols. This saw a drop in total cholesterol of 15-22% and a drop in LDL cholesterol (bad cholesterol) 10-22%. The results were slightly disappointing, however, when it was shown that 15% of patients did not show any improvement in their cholesterol levels. Trials on these patients thus continued with purely delta- and gamma-tocotrienols. After four weeks, cholesterol for these patients dropped 35-40%!
Tocotrienols are a good option for lowering cholesterol levels compared to the more standard cholesterol lowering option: statins. Statin drugs are used to inhibit LDL cholesterol, but are also associated with side effects, such as muscle pain and fatigue. This all has to deal with the mechanism in which Statin acts to lower cholesterol. Cholesterol synthesis occurs in a pathway (a series of chemical reactions that act in a step-wise fashion) starting from the initial enzyme which ends in the eventual creation of cholesterol. Statins are called competitive inhibitors of cholesterol synthesis. This means they works directly on the HMG CoA reductase enzyme (the protein responsible for initiating the cholesterol synthesis pathway) by competing directly with the normal substrate (the molecule on which the enzyme acts) for HMG CoA reductase. In this regard, statins are incredibly effective in reducing cholesterol levels by shutting down the pathway, but they unfortunately also reduce the production of some essential proteins in the process.
The synthesis of CoQ10 shares the same pathway involving HMG coA reductase. It is found further down the pathway than cholesterol synthesis, however, so the complete shutdown of the pathway from statins unfortunately halts CoQ10 synthesis as well. CoQ10 is a chemical naturally produced in our bodies. It is involved in the process of producing adenosine-5-triphosphate (or ATP) which is our cells major energy source. A CoQ10 deficiency can lead to congestive heart failure, chronic myopathy, reduced energy production, and chronic fatigue.
Tocotrienol is considered a ‘non-competitive’ inhibitor of HMG coA reductase. This is because it does not compete directly with HMG coA reudctase’s substrate in the same way that statin does. It actually works further down the synthesis pathway to down-regulate cholesterol synthesis. The tail of the tocotrienol molecule releases an intermediary molecule of the pathway. Your body recognizes this increase of that molecule so the pathway regulates itself by decreasing the reaction of HMG coA reductase (so as to not overproduce on that molecule). Tocotrienol has also been shown to degrade HMG coA reductase as well. Consequently, this reduces the production of cholesterol (since HMG coA reductase does not react) but does not reduce CoQ10 production (since the entire pathway isn’t shut down and the intermediary steps that lead to CoQ10 production are not hindered).
Dr. Teri Burnett is a plastic surgeon who has incorporated the Kyani Triangle of Health into her practice. The call took place on March 16th, 2011. In the call, Dr. Burnett explained why she decided to implement Kyani in her patient therapy. She also briefly described the benefits of each product.
Many of Dr. Burnett's patients require either skin care or wound healing after surgery. For this she prefers the use of natural products rather than traditional medicine. She describes how she saw many of her patients on a variety of medication. Some of her patients were on medications that were meant to combat the side effects of other medications! Getting good nutrition into her patients was important in order to heal them in a safe way.
The L-arginine problem
Many other products that produce Nitric Oxide in the body use L-arginine as a precursor. The difficulty with using L-arginine is that it can also be converted into 7 other compounds other than Nitric Oxide. Compounded with the fact that aging produces chemicals that can act to block the conversion into Nitric Oxide, the people who usually most need Nitric Oxide cannot efficiently produce it. L-arginine also can activate the reemergence of herpes simplex.
Kyani Nitro FX and its younger brother Kyani Nitro Xtreme use Noni extract as the precursor for Nitric Oxide. Dr. Burnett explains that about 10% of the Noni extract is converted into Nitric Oxide in the mouth (processed by our bacteria), 10-12% is converted in the stomach by our stomach acid (HCl acid), and the rest is converted in our intestine. The Nitric Oxide produced in our mouth and stomach enters our blood stream very quickly to be used by the rest of the body.
Nitro Xtreme is designed with athletes and those with chronic diseases in mind. Also added were nutrients that may be depleted in a lot of people. In addition to Noni, Nitro Xtreme included:
1)Niacin - acts to decrease cholesterol and is used in the formation of red blood cells.
2) Magnesium - used in approximately 300 reactions in the body such as the formation of DNA. It helps to lower both systolic and diastolic blood pressure. Also helps in the conversion of L-arginine (a protein produced naturally in the body)
3) Zinc - Used to improve your immune system. Also helps in the formation of collagen.
4) Chromium - Helps to reduce insulin resistance. Also decreases LDL and increases HDL.
5) CoQ10 - CoQ10 is essential for production of energy. It is found in lower amounts in those that are taking statin drugs for cholesterol.